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Histopathological studies on the spleen of guinea pigs during experimental fluorosis

Pooja Kumara, Wajda Nazb & Arbind Kumarb*
aIndira Gandhi Institute of Medical Sciences, Patna
bP.G.Department of Zoology, Patna University, Patna

Received 20th June, 2013  ;  Revised 26th July, 2013

Abstract : Fluoride is a well-known environmental pollutant worldwide getting entry into the body mainly through drinking water. Excessive intake of fluoride results in all the three forms of fluorosis viz. dental fluorosis, skeletal fluorosis and non-skeletal fluorosis. Our present experiment is designed to study the histopathological effects of sodium fluoride on the spleen in adult guinea pigs given orally 50 mg NaF/kg body weight per day for 65 days. Abnormalities in the spleen showed damaged trabecular appearance and prominent cracks in both white pulps and red pulps. The lymphatic nodules and periarterial lymphatic sheaths were very much obliterated. The number of lymphocytes were increased and iron pigments decreased in the red pulps. The lymphatic nodules were devoid of germinal centers and the overall splenic tissue was highly basophilic. These alterations in the spleen due to fluoride intoxication may lead to reduced immunogenic response and decreased hematopoiesis as observed in fluorosis patients from endemic zones.

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