Miss Anjali, Kunal Kumar & Hashmat Ali*
University Department of Chemistry, Sido Kanhu Murmu University, Dumka, Jharkhand, India
Received : 8th July, 2022 ; Revised : 9th August, 2022
Abstract– Complexes of p-fluorobenzoylthioacetophenone, an organic ligand with transition metal ion acts as multitherapeutic agents. They act as catalyst and in photosynthesis. These complexes have many applications in the form of medicines. The formation constants of the complexes of the said ligand with bivalent Manganese, Nickel, Cadmium and Mercury were determined at three different temperatures through Irving and Rossotti method. From a knowledge of Overall formation constants, Standard change in Free energy were determined at the said temperatures using thermodynamic relation ΔG° = -2.303 RT Log β. From the data obtained, the Standard Changes in free energy which contribute towards complex formation and which has a say in the therapeutic properties have been discussed.
Key words: Formation constants, Therapeutic properties, Free energy