Kunal Kumar, Nishant Soren & Hashmat Ali*
University Department of Chemistry, Sido Kanhu Murmu University, Dumka, Jharkhand, India
Received : 6th July, 2022 ; Revised : 7th August, 2022
Abstract– The complexes of para-chlorobenzoylthioacetophenone with Manganese, Nickel, Palladium have great Therapeutic uses. These complexes have been found curative in many acute diseases including breast cancer. Parachlorobenzoylacetophenone the ligand chosen for the present research work is an organic compound of Monothio-β- diketone class of compounds. This organic ligand behaves as uninegatively charged bidentate chelating agent. The overall Stability Constants of the said complexes have been determined potentiometrically. Thereafter, Standard Changes in Enthalpy accompanying complex formation were determined to know its contribution in complexation as also its therapeutic uses.
Key words: Overall Stability constant, Medicinal values, Enthalpy, Therapeutic uses, Free energy