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Role of nutmeg in minimizing hepatotoxicity due to arsenic in albino rats

Puja Mandala, Namita Lala* & Arun Kumarb
aDepartment of Zoology, Dr. Shyama Prasad Mukherjee University, Ranchi, Jharkhand, India
bScientist- I, Mahavir Cancer Institute & Research Centre, Phulwarisharif, Patna, Bihar, India
Received : 20th October, 2021 ; Revised : 24th December, 2021

Abstract– Arsenic is pervasive element in the environment and cause serious health problem in most of the countries. In India west Bengal, Bihar and Jharkhand found arsenic contamination in underground water. It causes serious health problem in human such as cancer in liver, kidney skin etc. It became severe in low-income nation such as Bangladesh. Arsenic out-turn into liver injury. In present study was conducted to evaluate the protective role of nutmeg (Myristica fragrans) against arsenic induced toxicity in albino rats. Albino rats were divided into three groups. Group A were control rat, group B received an acute dose of arsenic (8mg/kg bw) orally, group C received an acute dose of arsenic followed by daily administration of nutmeg (300mg/kg bw) orally. Arsenic treatment leads to increase in the liver injury. Biochemical analyses of treatment group show Arsenic induced rats had significantly (p\0.0001) found the changed serum levels of Serum Glutamic-Pyruvic Transaminase (SGPT), Serum Glutamic-Oxaloacetic Transaminase (SGOT), Alkaline Phosphatase (ALP), total bilirubin, urea, uric acid, creatinine and albumin and its degenerative effect; But, after the administration of M. fragrans extract, there was significant (p<0.0001) restoration observed in these liver and kidney function. Nutmeg become significant protection in the palliation of arsenic induced liver injury. The aim of the present review is to introduce Myristica fragrans as a potent medicinal property by highlighting its pharmacological and clinical application.

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