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Prolonged colchicine induced nephrotoxicity in albino rat

Suman Swaraj*
Department of Zoology, B.N.Mandal University, Madhepura, Bihar, India
Received : 16th May, 2020 ; Revised :25th June 2020

Abstract- As follow up of previous investigation on effect of prolonged use of colchicine alkaloid on the hepatic tissues (hepatotoxicity) in albino rats, the present communication deals with the picture of nephrotoxicity in terms of renal function tests result carried out in the same subject simultaneously experiencing the prolonged treatment of intraperitonnial injection of different concentration of colchicine for a period of three months. The observed biochemical assay of centrifused blood serum of treated rats for renal function test were serum creatinine (SC) & serum urea (SU) as per the standard protocol of Wilding & Kennedy (1977)1 and Alexander Griffith (1992)2. Results obtained have been found to be statistically significant, establishing the toxic impact of the alkaloid colchicine on the kidney of albino rats.

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