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Altered serum protein level in fresh water teleost: a potential bioindicator of endosulfan induced nephrotoxicity

Prakash Singh, Rizwan Ahmad & G.B. Chand*
Aquatic Toxicology Laboratory, Department of Zoology, Patna University, Patna, Bihar, India
Received : 22nd April, 2020 ; Revised : 26th May, 2020

Abstract Persistent Organic Pollutants (POPs) are constantly being used as modern agrochemical in Indian agriculture despite banned globally and in many of the States of India.The residues of endosulfan, aPOP of organochlorine group, reach water bodies mostly through agricultural runoff and causes severe damage to aquatic fauna predominantly to fishes. They come in direct exposure to this toxic chemical, which has been implicated a gradual toxicity, neurotoxicity, hepatotoxicity, nephrotoxicity and various other biochemical alterations in fishes. The present study is designed to study the alterations in total protein and albumin in the blood serum of Clarias batrachus after exposure to various concentration of endosulfan in a dose as well as duration dependent manner. After statistical analysis of the data, it has been observed that alterations generated in total protein and albumin are highly significant (p>0.001). This may be due to deteriorating effects of endosulfan
on glomerular fenestrae. The results indicate the nephrotoxic effect of endosulfan in fishes.

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