Ultrastructural studies on the testes and liver of mice after treatment with different doses of Diclofenac Sodium.

Deepak Mohan^a* & Sushma Sharma^a
a*Department of Biosciences, Himachal Pradesh University, Summer Hill, Shimla H.P.
Received 05th November, 2013; Revised 20th December, 2013

Abstract : Diclofenac sodium is one of the most common non-steroidal compounds of phenyl acetic acid class, binds extensively to plasma albumin and having inhibitory effects on prostaglandin biosynthesis. The present investigation was conducted to reveal the effect of diclofenac sodium (4mg/kg body weight and 14 mg/kg body weight) on testes and liver of mice at ultrastructural level. Electron microscopic study revealed changes in testes seminiferous tubules such as degenerative changes in mitochondria, endoplasmic reticulum, Golgi bodies etc. Spermatogonia showed apoptotic changes in the form of nuclear chromatin condensation and deeply stained cytoplasm. Similar changes were also observed in the hepatocytes of liver.

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