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In vivo biochemical alterations and associated nephrotoxicity in Clarias batrachus (Linn.) due to pesticide exposure.

Prakriti Vermaa*, Zakia Khatoona & Prabha Rania
*aDepartment of Zoology, Patna University, Patna- 800 005, Bihar, India.
Received 22nd October, 2013; Revised 30th December, 2013

Abstract : The present study was carried out in order to assess the synergistic or antagonistic action of rogor and endosulfan induced toxicity in air breathing fish. Fresh catfish Clarias batrachus were exposed to dimethoate (o,odimethyl,S-methyl-carbamoyl-methyl phosporodithioate) and organochlorine endosulfan pesticides commonly used in agricultural field with a dose of 0.004 µl/L endosulphan,1 µl/L rogor and a combination dose of {rogor(1 µl/L) + endosulfan (0.008 µl/L)} for 21 days . Every week blood was collected for serum biochemical analysis. Kidney tissues were dissected to see any histopathological changes viz. degeneration of epithelial cells uriniferous tubules, vacuolation,
cytoplasmic shrinkage and shrinkage in glomerular network increases with the dose and duration of the pesticide exposure. Serum biochemical analysis also reveals increasing urea and decreasing protein level throughout the experimental period as compared to normal. Endosulfan was found more toxic than rogor as indicated by the biochemical analysis and histopathology of kidney cell. Administration of rogor and endosulfan in combined dose was found more toxic in comparison to individual treatment. It has been concluded that rogor and endosulfan sets a wave of biochemical
imbalance and leading to nephrotoxicity.

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