Biological importance of vanadium complexes with sythesised ligand of derived Schiff base.

Neetu^a*,  K.N.Thakur^b, R.K.Singha & K.Swarnim^c
aDeptt. of Applied Chemistry, Cambridge Institute of Technology, Tatisilwai, Ranchi, Jharkhand, India.
^bDeptt. of Chemistry, Ranchi college, Ranchi Univerisyt, Ranchi, Jharkhand, India.
^cDeptt. of Zoology, Ranchi Women’s college, Ranchi University, Ranchi, Jharkhand, India.

Received 27th December, 2011; Revised 19th February, 2012

Abstract :Four unsymmetrical and five symmetrical Schiff base complexes of oxovanadium (IV) have been tested in vivo for their insulin mimetic activities .An acute oral administration of four asymmetrical Schiff base complexes of oxovanadium (IV) elicited a progressive reduction in plasma glucose over six hrs in STZ rats. Two of the asymmetrical Schiff base complexes oxovanadium (IV)induced a significant reduction in plasma glucose over a six hrs period .oral administration of five symmetrical complexes also elicited a progressive reduction in plasma glucose in six hrs. Two of these complexes induced a significant reduction in plasma glucose during six hrs period.