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Pyrethrin induced changes in enzymological activities (GOT, GPT, ACP and ALP) in liver and kidney of freshwater fish Clarias batrachus L.

Sarita Murmu, J.A.Ganaie, A. Khan & V.K. Shrivastava*
Endocrinology lab. Department of Biosciences, Barkatullah University, Bhopal – 462 026 (M.P) India Received 16th Feb. 2007; Revised 08th March, 2007

Abstract : 30 adult fish Clarias batrachus weighing about 180 to 200 g. were divided into three groups of ten each. Group I served as control received only fish diet, Group H received vehicle i.e. 5 ppm of absolute alcohol and group III received a mixture of alcohol and pyrethrin (5:0.05 ppm) for 15 and 30 days. Fish were sacrificed on day 16th and 31st and various enzyme activities i.e. GOT, GPT, ACP and ALP were estimated in liver and kidney. Pyrethrin elevated the levels of GOT and GPT activities in liver and kidney after 15 and 30 days, when compared with control groups. The significant values were noted in later part of the experiment. However, pyrethrin lowered the hepatic and renal ACP and ALP enzyme activities of Clarias batrachus after 15 and 30 days. These observations suggest that pyrethrin impairs hepatic and renal functional activities by modulating the enzyme activities, and these effects are to be dose and duration dependents.

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