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Caspases; the killer in the ovary: An overview

Bhola Paswan, Shamshun Nehar, Bushra Raza & Di pali Raha
Department of Zoology, Ranchi University, Ranchi – India

Received 20th Dec. 2006; Revised 5th Feb. 2007

 Abstracts: Programmed cell death or apoptosis is currently the hottest area of modern biology. It describes an orchestrated collapse of cell, staging membrane blebbing, cell shrinkage, protein fragmentation, condensation and DNA fragmentation followed by rapid engulfment of the corpse by neighboring cells. The excitement ensued when that apoptosis is an essential part of life for any multicellular organism and that the way in which most of the cells die is conserved from worms to mammals. Apoptosis is obligatory for harmonious cell life in animals from the cavitations of the early embryo to the removal of infected or cancerous cells in the adult. At the center of this death process is a family of proteases called caspases (Where ‘c’ is intended to reflect cystein protease and aspase is ablity to cleave after aspartic acid, the most distintict feature). Relatively little attention has been focused upon the ovary with regard to elucidating member of caspases and pathway by which they are activated and inactivated. Using mouse knock out model system evidences has been gathered about the role of caspases in the ovary.

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