Deepak Rawal * & Yamini Suthar
Department of Zoology, Mohanlal Sukhadia University Udaipur, India
Received : 30th November, 2023 ; Revised : 05th January, 2024
DOI:-https://doi.org/10.5281/zenodo.13999560
Abstract– CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a genome editing technology. It is a general notion that if we decode genome, we can decode the key of life. The hope and hype associated with CRISPR carry the same notion. The CRISPR-Cas system, derived from a bacterial adaptive immune mechanism, has emerged as a groundbreaking tool for genome editing. Its precision, efficiency, and adaptability have transformed basic research, biotechnology, and hold immense promise for treating genetic diseases. This review article investigates the fundamental principles of CRISPR-Cas systems, delves into their diverse applications, discusses present challenges, and explores the ethical considerations surrounding this revolutionary technology. CRISPR-Cas systems, once an obscure mechanism of bacterial immunity, have transformed our ability to manipulate the genome with unprecedented precision. This review delves into the evolutionary origins of CRISPR, explores the key technological breakthroughs fueling its applications, and discusses the profound implications for scientific research, biotechnology, and the treatment of genetic diseases. While ethical considerations and technical challenges remain, CRISPR stands poised to rewrite the biological landscape and fundamentally shift our approach to health and disease.
Key words: CRISPR, epigenetic, genome, phenotype, Cas9
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