Chanchal Choudhary & Shweta Saran*
School of Life Sciences, Jawaharlal Nehru University, New Delhi, India
Received : 08th December, 2023 ; Revised : 15th January, 2024
DOI:-https://doi.org/10.5281/zenodo.14062730
Abstract– Translationally-Controlled Tumour Protein (TCTP) is an evolutionarily conserved protein throughout eukaryotic species. It is a multifunctional protein, involved in diverse biological mechanisms, e.g. cell growth, cell proliferation, cell cycle, cell death, stress and immune responses. It is identified as an apoptosis-inhibitory protein, hence associated with tumour progression. Expression is controlled both at transcriptional and translational levels. Dysregulation of TCTP leads to a range of diseases. TCTP in Dictyostelium discoideum has two isoforms called TPT1 and TPT2. Our previous findings showed the involvement of TPT1 in growth and development-related functions. Studying the roles of TPT proteins is crucial for comprehending their biology in its whole. In this study, we focus on in silico aspects of DdTPTs. This study explores the TPT proteins at molecular levels of organisation and their functional interacting partners alongside human TCTP. The fundamentally conserved mechanisms are suggested by the common interacting partners and shared homology between DdTPTs and human TCTP.
Key words: TCTP, Dictyostelium, in-silico, Interactions
