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Magnetic and in-vitro biochemical study of Ni (II) complexed with piperazinedibiguanide ligand

Madhu Kumari Guptaa* & Bina Ranib
aDepartment of Chemistry, Magadh Mahila College, Patna University, Patna, Bihar, India
bUniversity Department of Chemistry, Patna University, Patna, Bihar, India
Received : 20th August, 2021 ; Revised : 20th September, 2021

Abstract– Biguanide and substituted biguanides have long been used in biomedical science. A very common example is metformin which is used as oral antihyperglycemic drugs. Similarly, many other substituted biguanides such as polyaminopropyl biguanide (PAPB) and Proguanil used as disinfectant and antimalarial drugs respectively. Biguanide and substituted biguanide also act as very good nitrogen donor ligand for the preparation of coordination complexes with transition metal ions. Since long time synthesis of different substituted biguanides have been done and then its characterization was studied by different researchers. Biochemical studies are also going on for the complexes so that it can be used as either drug or antimicrobial agents. In this research paper, the authors have tried to find out antifungal property of piperazinedibiguanide ligand when complexed with Ni(II) metal ions. The authors have first prepared the ligand and then complexed it with metal ion by reacting with metal salts. Elemental percentage was estimated and magnetic behavior was studied. Further the complexes so obtained tested for fungal growth inhibition by disc dilution test method in both PDA and SDA media. The antifungal activity was done against two ascomycetes. While doing the test, the concentrations of piperazinedibiguanide complexes used were 400, 200 and 100μg/ml. A positive response was obtained against both Aspergillus niger and Aspergillus versicolor.

Key words: Aspergillus niger, Aspergillus versicolor, PDA, SDA, ascomycetes

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