Md. Amzad Khan*, Deepshikha Samdershi, Priyanka Kujur, Haque Sana, Kumari Neetu & Suhasini Besra
University Department of Zoology, Ranchi University, Ranchi, Jharkhand, India
Received : 04th January, 2021 ; Revised : 3rd February, 2021
Abstract : The aqueous leaf extract of Achyranthes aspera was evaluated for its ameliorative effect in the regulation of hypothyroidism induced by methimazole in male albino rats. Rats were divided into four groups, three for each. Group I (control), group II (hypothyroid control) normal rats administered orally with methimazole 25 (mg/kg bwt.) for five successive days, treated group III and group IV with aqueous leaf extract of Achyranthes aspera 400 (mg/kg bwt.) for 14 and 28 days respectively, after hypothyroidism. Statistical analysis was done using student’s t test. The obtained results revealed that hypothyroidism induced group II showed significant decrease in serum T3 and T4(p<0.001), a significant increase in serum TSH was also observed (p<0.001), when compared to control group I. It was also observed that treated group III and group IV with aqueous leaf extract of Achyranthes aspera 400 (mg/kg bwt.) for 14 and 28 days respectively, after hypothyroidism showed significant increase in serum T3 and T4(p<0.001), a significant decrease in serum TSH content was also observed, when compared with hypothyroid control group II. To conclude, aqueous extract of Achyranthes aspera leaf could be a potential therapeutic alternative for the management of hypothyroidism.