Antidiabetic potential of a novel hypoglycemic active principle from bittergourd (Momordica charantia) seeds in alloxan-induced diabetic rats.

Zamiruddin Ansari^a*, Vinay Bhushan Kumar^b, Shree Ram Padmadeo^c & Anand Mohan^d
ªDepartment of Biochemistry, Patna University, Patna, Bihar, India
^bDepartment of Botany, T.P.S. College, Patna, Patliputra University, Patna, Bihar, India
^cDepartment of Botany, Patna University, Patna, Bihar, India
^dDepartment of Biotechiology, College of Commerece, Arts & Science, Patna, Bihar, India
Received : 23rd April, 2020 ; Revised : 21st May, 2020

Abstract–The present study evaluates antidiabetic potential of fractionated bittergourd (Momordica charantia) seed extracts in alloxan-induced diabetic rats. A novel hypoglycemic active principle (MCK3P8) obtained from a fraction of the ethanolic extract (MCK3) of bittergourd (Momordica charantia) seeds, given by intraperitoneal injection to alloxan-induced diabetic rats at a dose of 15 mg/kg b.wt., showed a significant hypoglycemic activity. Loss in hypoglycemic activity of the MCK3P8
upon proteinase-K treatment indicates the proteinaceous nature of the novel hypoglycemic active principle.

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