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Effect of sodium fluoride on the rat liver

Satish Kumar Sah*& Arun Kumar
University Department of Zoology, B.N.M University, Madhepura, Bihar, India
Received : 02ndFebruary, 2020; Revised : 28th February, 2020

Abstract : Sodium fluoride (NaF) is used for caries prevention in the form of fluoridated drinking water etc. Effect of fluorides on various metabolic levels in hard and soft tissues, namely respiration as well as carbohydrate, protein, enzymatic and vascular metabolism, can disturb detoxication of fluorine compounds administered orally. The study objective was to study the effect on liver of young and mature rats exposed to NaF in drinking water from conception till maturity, as well as after its withdrawal. The results observed in the liver, can help determine to what degree of oral fluoride caries prevention is safe and whether it should be implemented.

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