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Biochemical changes in the testes of mice after treatment with different doses of diclofenac sodium

Deepak Mohana* & Sushma Sharmaa
a*Dept. of Zoology, S.C.V.B. Govt. College, Palampur, Himachal Pradesh. 176061
Received , 30th November, 2014; Revised: 10th December, 2014

Abstract : Diclofenac sodium (DS), a well-known member of acetic acid family of non-steroidal anti-inflammatory drugs (NSAIDs) is used to reduce inflammation and pain associated with arthritis, osteoarthritis and ankylosing spondylitis. The drug is one of the most common non-steroidal compounds which bind extensively to plasma albumin, having inhibitory effects on prostaglandin biosynthesis. The continuous use of diclofenac for short term relief from discomforts due to ailments paves way for the development of complications in the reproductive system. The present study is focussed on the effect of different doses of diclofenac sodium (4mg/kg/body weight and 14mg/kg/ body weight) on different biochemical parameters like acid and alkaline phosphatase, aminotransferases like GOT/GPT and lipid peroxidation on testes of mice. A Significant decrease in the specific activity of acid and alkaline phosphatase was observed in both low and high dose groups after different days of DS treatment. The present study also revealed a decrease in the specific activity in the mice testes after 28 days of treatment. The increased concentration of malondialdehyde in the mice testes observed in the present study indicated the toxicity of diclofenac resulting in enhanced lipid peroxidation.

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