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Antibacterial activity of Cassia auriculata against ESBL producing E.Coli from UTI patients

Ishwari Prasad Guptaa* & Arpana Sinhaa
*aP.G. Dept. of Botany, Ranchi College, Ranchi, Jharkhand, India.

Received 20th October, 2012; Revised 25th November, 2012

Abstract : Urinary tract infection (UTI) is one of the most common diseases among all age groups encountered in medical practice today. The increasing drug resistance of bacteria has made the therapy of UTI difficult and has led to greater use of expensive broad spectrum drugs. The aim of the study was to evaluate the antibacterial efficacy of Cassia auriculata against Extended Spectrum Beta Lactamase (ESBL) producing E. Coli. Methanal, Ethanal, ethyl acetate, hexane and chloroform crude and soxhlet extracts of ethyl acetate and hexane of leaves and flowers of Cassia auriculata were tested for antibacterial activity by well diffusion method against ESBL producing E. Coli. It was concluded that Cassia auriculata has antibacterial activity against ESBL producing E. Coli from UTI. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of the ethyl acetate leaves and flowers extract were evaluated. The maximum activity was observed from a range between 50-125 mg/ml.
Key words: ESBL , urinary tract infection, C. auriculata, Minimum inhibitory concentration, E. Coli.


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