Rajneesh Kumar & Pooja Singh*
Bacteriology and Natural Pesticide Laboratory, Department of Botany, Deen Dayal Upadhyaya Gorakhpur University, Gorakhpur, Uttar Pradesh, India
Received : 04th December, 2023 ; Revised : 05th January, 2024
DOI:-https://doi.org/10.5281/zenodo.14263432
Abstract– Herpes simplex virus type 1 (HSV-1) and type-2 (HSV-2) are extensively prevalent, infectious human pathogens causing oral and genital lesions as primary infections. They establish a latent neural infection reservoir in neural ganglion and occasionally there is recurrence in response to various physiological stimulants after primary infection. Additionally, associated infection includes herpes keratitis, encephalitis, blindness, and genital tract inflammation. Acyclovir, Famciclovir, Valacyclovir and their derivatives are generally used for the treatment of HSV but the development of resistance and side effects limit potential use of drugs against it. Plants have bewildering nature of prophylaxis agents which can used to harnessed to treat various disease ailments. Botanicals i.e. plant’s essential oil, extracts and isolated compounds have antiviral activity against HSV with the diverse mode of action to treat the herpetic infections. This review aims to summarise the current status of knowledge of the use of botanicals as antiviral agent against Herpes Simplex Virus.
Key words: Herpes Simplex Virus, Botanicals, Antiviral, Prophylaxis, Antiviral Mechanism.
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