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Arsenic induced renal toxicity and its correlation with high lipid peroxidation in swiss albino mice

Puja Anand* & Preety Sinha
Department of Zoology, A.N College, Magadh University, Bodh Gaya, Bihar, India
Received : 17th November, 2021 ; Revised : 6th January, 2022

Abstract– Around the world, millions of people get exposed to a high level of heavy metals through their drinking water. Among these metals, Arsenic is one of the most potent toxic agent and prevalent in the environment in its inorganic form i.e. Sodium Arsenite (NaAsO2). Sodium Arsenite is observed to possess high reactivity with thiol groups. The present study was conducted to investigate the effects of low doses of Sodium Arsenite on kidney and its correlations with oxidative stress in Swiss albino mice. Mice were dissected for histological & lipid per oxidation evaluation after 4th, 6th and 8th weeks. Significant rise in lipid per oxidation was observed in Sodium Arsenite dosed Swiss albino mice. Mild to severe types of necrosis and degenerative changes in the kidney via histological studies were noticed. Mononuclear cell infiltration and vacuolization in the tubules resulted in reduced glomerulus space. It could be safely concluded that degenerative changes in kidney tubular epithelium may be attributed to Arsenic. Metabolites of Arsenic which are excreted from kidneys may also cause cellular damage leading to kidney dysfunction. These findings in mice model might be useful for a better understanding of the toxic effects of Arsenic, to develop an effective ameliorative treatment against Arsenic mediated effects on human health.

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