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Antidiabetic potential of a novel hypoglycemic active principle from bittergourd (Momordica charantia) seeds in alloxan-induced diabetic rats.

Zamiruddin Ansaria*, Vinay Bhushan Kumarb, Shree Ram Padmadeoc & Anand Mohand
ªDepartment of Biochemistry, Patna University, Patna, Bihar, India
bDepartment of Botany, T.P.S. College, Patna, Patliputra University, Patna, Bihar, India
cDepartment of Botany, Patna University, Patna, Bihar, India
dDepartment of Biotechiology, College of Commerece, Arts & Science, Patna, Bihar, India
Received : 23rd April, 2020 ; Revised : 21st May, 2020

AbstractThe present study evaluates antidiabetic potential of fractionated bittergourd (Momordica charantia) seed extracts in alloxan-induced diabetic rats. A novel hypoglycemic active principle (MCK3P8) obtained from a fraction of the ethanolic extract (MCK3) of bittergourd (Momordica charantia) seeds, given by intraperitoneal injection to alloxan-induced diabetic rats at a dose of 15 mg/kg b.wt., showed a significant hypoglycemic activity. Loss in hypoglycemic activity of the MCK3P8
upon proteinase-K treatment indicates the proteinaceous nature of the novel hypoglycemic active principle.

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