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Daidzein affects leptin hormone secretion in the male Wistar rat

Sweta Kumari* and Nayni Saxena
University Department of Zoology, Ranchi University, Ranchi, Jharkhand, India
Received :16th May, 2019 ; Revised : 11th July, 2019

Abstract : Daidzein (7, 4 dihydroxy isoflavone) is a naturally occurring isoflavone present in a number of plants, especially in soybeans and soy-derived products. The influence of this isoflavone, daidzein on leptin hormone was studied in sexually mature Wistar rats. Rats were divided into three groups: Control (received no daidzein), Sham control [received vehicle as ethanol: saline water (1:9)] and Experimental group [received daidzein 15mg/kg body weight (bw)]. Daidzein was administered intragastrically, i.e. by using a cannula inserted via oesophagus into the stomach once a day for 15, 30 and 60 continuous days. In animals treated with daidzein blood leptin-hormone level was significantly reduced. After 15 days, the effect was less significant (p<0.05) as compared to that observed after long duration administration for 30 and 60 days (p<0.001).This latter effect was probably due to direct inhibitory influence of daidzein on leptin-hormone secretion from adipocytes. Results obtained in the study indicate that daidzein may affect leptin hormone responsible for metabolism, energy expenditure and food intake in Wistar rat.

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