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Role of chromium complexes in pharmaceutical industries

Richa Kumari*
Department of Chemistry, S.S.Memorial College, Ranchi University, Ranchi, Jharkhand, India
Received :1st October, 2017 ; Revised :23rd December, 2017

Abstract : Chromium has an atomic weight of 51.996. The element may occur in compounds in di-, tri-, or hexavalent forms. Hexavalent chromium is the highest oxidation state of elemental chromium. Trivalent chromium is the most stable oxidation state for chromium, and it is this form that is found in common nutritional supplements, generally as the picolinate. Chromium supplementation has been studied for a variety of indications, especially diabetes and weight loss, but clinical studies have shown inconsistent results. To date, no chromium-containing biomolecules have been definitively described, and no clinical manifestation of trivalent chromium deficiency in humans has been established. The argument for chromium supplementation relies on evidence from case reports of resolution of diabetic symptoms refractory to insulin via chromium added to total parenteral nutrition, and experiments in which animals deficient in chromium exhibited impaired glucose metabolism. The chromium hydrochloride complex as a diabetic drug model was synthesized by the chemical reaction between chromium (III) chloride hexahydrateand metforminHCl (Mfn.HCl) in methanol solvent (III) metformin.

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