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Effect of tetracycline on the haematology of Hepatozoon infected Rana tigrina

Reena Rastogi & Neelima Gupta*
Department of Animal Science, M J P Rohilkhand University, Bareilly-243 006(U.P) INDIA

Received 2nd Jan. 2007; Revied 21st Feb. 2007

Abstract: Tetracycline was administered orally at a dose of 8.25 mg/100 gm body weight of R.tigrina to a group of 10 frogs and the parasitaemia and the haematological parameters ( Hb%, TLC and TEC ) were recorded and compared with those of control groups. Hepatozoon – infected Rana showed a decline in Hb concentration from 12.66 to 11.71 gm/100 ml but when administered with tetracycline, the Hb turned towards the normal value of 13.0 gm/100 ml. The total leukocyte count increased from 3.66 X 104/cmm to 4.84 X 104/cmm in infected frogs but when treated with tetracycline, the value slightly fell to 4.71 X 104/ cmm. The TEC in Hepatozoon infected Rana again declined to 3.0 X 105/cmm of blood from the control value of 4.0 X 105/cmm of blood but in the antibiotic treated Rana, the TEC value increased to 3.2 X 105/ cmm of blood. The parasitaemia prior to treatment ranged from 1-2 parasite/100 RBC but after antibiotic treatment, the parasite number decreased to 1-2/500 RBC. The study indicates that the haematological values declined ( Hb%, TEC ) or elevated ( TLC) in Hepatozoon – infected Rana as compared to the control values but when the infected frogs were ‘treated with tetracycline, the haematological values turned towards normalcy and the parasitaemia also decreased. The studies indicate that tetracycline may be effectively used for the treatment of Hepatozoon – infected Rana at a dose of 8.25 mg/100 gm body weight.

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