Anshu Ankita Bara* & Jyoti Kumar
University Department of Botany, Ranchi University, Ranchi, Jharkhand, India
Received : 12th December, 2023 ; Revised : 13th January, 2024
DOI:-https://doi.org/10.5281/zenodo.14292024
Abstract– The rising global threat of antibiotic resistance underscores the urgent need to discover new antimicrobial agents. This study focuses on isolating and characterizing unique strains of soil bacteria associated with solanaceous plants in Ranchi, India, with the aim of identifying novel antibiotic compounds. A diverse range of solanaceous plants, such as tomatoes, potatoes, and peppers, have been traditionally known to host microorganisms with unique metabolic capabilities. These plant-associated bacteria often exhibit promising bioactive properties, including the production of antibiotics that may prove effective against multi-drug-resistant pathogens. In this research, soil samples were collected from various solanaceous plant rhizospheres in the Ranchi region. These samples were processed through selective isolation techniques to obtain pure bacterial cultures. The isolated strains were then studied for various morphological and biochemical tests to evaluate their antibiotic-producing potential. Initial screening revealed a rich diversity of soil bacteria, which include different genera, each with its own unique characteristics and classifications. Subsequently, the crude extracts were subjected to bioassays against a panel of pathogenic bacteria, including drug-resistant strains, to assess their antibiotic activity. The results demonstrated the presence of promising antibiotic-producing strains with broad-spectrum activity This study’s findings offer potential leads for the development of novel antibiotics from soil bacteria associated with solanaceous plants in Ranchi. Such antibiotics hold promise in combatting the global health challenge posed by antibiotic-resistant pathogens, emphasizing the importance of harnessing the microbial diversity within our soil ecosystems to address this critical issue.
Key words: soil microbes, bacterial strains, drug discovery, bioactive compounds, novel antibiotics
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