Khushboo Tiggaa* & Deepshikha Samdershib
aDepartment of Zoology, S.P. Mahila College, Dumka, S.K.M. University, Dumka, Jharkhand, India
bUniversity Department of Zoology, Ranchi University, Ranchi, Jharkhand, India
Received : 15th January, 2025 ; Revised : 14th February, 2025
DOI:-https://doi.org/10.5281/zenodo.15978554
Abstract– In this experiment an investigation was made to analyze the effect of ovariectomy on the cyclicity and compensatory ovarian hypertrophy in female laboratory rats. Various parameters were used to study this phenomenon such as Unilateral Ovariectomy (ULO) and Bilateral Ovariectomy (BLO) and daily estrous cycle was observed till 4th week. Body weight, weight of remaining ovary (in unilateral Ovariectomy), adrenal weight, uterus weight and total protein content in uterus was observed. Control group were showing 4-day estrous cycle, bilateral Ovariectomy group completely lost the estrous cycle and underwent permanent diestrus stage whereas ULO group had irregular estrous cycle but within 21 ± 2 days they gained their estrous cycle and showed 4-day estrous cycle. Significant body weight gain was observed in BLO group as compared to ULO group (p<0.001). The ovarian weight in ULO group showed significant increase as compared to control group (p<0.001). Total protein was significantly reduced in bilateral ovariectomy group as compared to control group and unilateral ovariectomy group (p<0.001). These results supported that in ULO group during compensation of remaining ovary the cyclicity was irregular due to removal of one ovary (source of estrogen decreases) but after compensation estrous cycle become regular.
Keywords: Ovariectomy, Estrous cycle, Cyclicity, Hypertrophy, Diestrus
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