Bimlendu Kumar Roy*
Department of Sports Science (Biomedical Science for Health), University of Milan, Italy.
Department of Biochemistry, Devki Mahavir Homeopathic Medical College & Research Hospital, Garhwa, Jharkhand, India
Received : 29th May, 2024 ; Revised : 28th June, 2024
DOI:-https://doi.org/10.5281/zenodo.15003012
Abstract– Type 1 Diabetes (T1D) is a chronic autoimmune disease characterized by the destruction of insulin-producing beta cells in the pancreas, resulting in lifelong insulin dependence. The Non-Obese Diabetic (NOD) mouse is a widely used model for studying T1D, sharing many physiological and immunological features with the human form of the disease. This review examines the impact of early-life exercise on type 1 diabetes (T1D) development in non-obese diabetic (NOD) mice. Physical activity during early developmental stages shows promising potential in modulating immune responses and metabolic parameters that influence T1D progression. The review synthesizes current understanding of exercise-induced immunological changes, β-cell preservation mechanisms, and systemic effects in the NOD mouse model. Evidence suggests that early-life exercise may serve as a preventive strategy through multiple pathways, including enhanced immunoregulation and improved metabolic function. The findings provide valuable insights for developing exercise- based interventions for human populations at risk for T1D.
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