Effect of methanolic extract of Catharanthus roseus flower in alloxan induced diabetic albino mice through biochemical and metabolic changes assessment.

Madhuri Priyadarshini^a, RajKumar Singh^b* & Shashi Bhushan Lal^c
aDepartment of Botany, D. C. College, Hajipur, Bihar, India
^bDepartment of Zoology, D. C. College, Hajipur, Bihar, India
^cDepartment of Zoology, B. N. College, Patna University, Patna, Bihar, India

Received : 08th May, 2024 ; Revised : 05th June, 2024
DOI:-https://doi.org/10.5281/zenodo.15109006

Abstract– Diabetes mellitus (DM) is a common endocrine condition that affects how proteins, fats, and carbohydrates are metabolised. It is typified by persistent hyperglycaemia brought on by decreased insulin secretion, action, or both. Traditional treatments for Diabetes mellitus (DM), a serious metabolic condition, involve the use of a number of medicinal plants. Among these is the medicinal herb Catharanthus roseus. In the herbal medicine system, the plant has been used to treat diabetes mellitus since ancient times. In preclinical research, the medicinal plant Catharanthus roseus, which has long been used to treat diabetes, has demonstrated promise in lowering blood sugar levels and oxidative stress. In this work, mice with diabetes induced by alloxan are used to test the antidiabetic effectiveness of Catharanthus roseus flower extract. According to the results, Catharanthus roseus flower extract has benefits similar to those of rosiglitazone in lowering blood glucose levels and renal dysfunction indicators such as blood urea, creatinine, SGOT, and SGPT. These results highlight Catharanthus roseus’s therapeutic advantages and wider applicability in diabetes treatment, hence supporting its potential as a viable botanical therapy for the long-term control of Diabetes mellitus.

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