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Effect of Phyllanthus niruri leaves extract on urinary stone forming minerals

Alokita Kashyap* & Basabi Mahapatra
Department of Chemistry, Patna University, Patna, Bihar, India
Received : 22nd April, 2020 ; Revised : 19th May, 2020

AbstractFaced with the growing evidence that stone disease is of recurrent in nature, variety of substances have been used in an effort to dissolve renal stones and to prevent recurrence. In modern medicine, allopurinol and D-penicillamine are the effective drugs for dissolution and control of recurrence of uric acid and cysteine calculus, but we hardly have any effective and useful drug for the treatment of calcium oxalate, calcium phosphate and mixed type of stones. In present work we are reporting the inhibition efficiency of Phyllanthus niruri leaves extract towards the mineralisation and demineralisation of calcium oxalate, calcium phosphate and calcium carbonate. We have also estimated the phosphate content of the above natural product extract. Phyllanthus niruri popularly known as “Stone-breaker” is a plant belonging to Euphorbiaceae family with a worldwide distribution. More than 50 compounds were identified in Phyllanthus niruri, including alkaloids flavanoids, lignans and triterpenes. Interestingly, given that the maintenance of normal levels of calcium is critical to the function of many plants including plant rigidity, protection, detoxification (heavy metals or oxalic acid), ion balance and even light reflection and because high cellular free calcium concentration is dangerous for these organising higher plant developed very efficient way to neutralise Ca2+ ions, by forming complex with oxalate.

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