Deepshikha* & B. P. Yadav
University Department of Zoology, B. N. Mandal University, Madhepura, Bihar, India
Received : 12th August, 2018 ; Revised :24th October, 2018
Abstract: The effects of cobalt and manganese ions on some key enzymes in the kidney of rat were recorded. Cobalt, manganese and Arsenic invariably inhibited the activity of alkaline phosphatase, acid phosphatase, glucose-6- phosphatase and cholinesterase. However, manganese exposed rats showed an elevation in the activity of lipase while cobalt decreased the activity. After a combined treatment with cobalt manganese and Arsenic the activity of enzymes returns towards normal status indicating antagonistic behavior of these essential trace elements. However Arsenic is a cumulative poison and considered as very toxic metalloid that causes oxidative stress.