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Identity of the 3D structure of Envelope Small Membrane Protein (ESMP) of human SARS coronavirus (SARS-CoV : Severe acute respiratory syndrome coronavirus) using homology modeling

Pratima Bajpai* & Harish Dhingra
Faculty of Mody Institute Of Technology & Science, FASC, Lakshmangarh (332311) Rajasthan, INDIA.
Received 13th May, 2010; Revised 8th August, 2010

Abstract : Homology modelling is an important computational technique, within structural biology, to determine the 3D structure of proteins. It uses available high-resolution protein structures to produce a model of a protein of similar, but unknown, structure. We describe the essential steps in the process, and discuss the circumstances in which homology modelling is likely to lead to a useful result. Homology modelling plays a valuable role in drug design, and we illustrate this by one example, anti-SARS inhibitors.


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